PEDIATRICS Vol. 69 No. 6 June 1982, pp. 810-812
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Peter, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Peter, G.

Aspirin and Reye Syndrome

Committee on Infectious Diseases, Vincent A. Fulginiti MD, Philip A. Brunell MD, James D. Cherry MD, Walton L. Ector MD, Anne A. Gershon MD, Samuel P. Gotoff MD, Walter T. Hughes Jr MD, Edward A. Mortimer Jr MD, and Georges Peter MD

Because of the unique nature and importance of this report, the Committee urges that members read it in its entirety, and examine the report of the Reye Syndrome Working Group convened by the Centers for Disease Control (National surveillance of Reye syndrome 1981: Update, Reye syndrome and salicylate usage. Morbidity Mortality Weekly Rep 31:53-56, 61-63, 1982).

For some years there has been a suspicion that Reye syndrome is due, at least in part, to one or more drugs administered during an antecedent viral illness, usually influenza or chickenpox. Suspected drugs have included antiemetic and antipyretic preparations. More recently, concern has centered on salicylates.

In November 1980, summaries of epidemiologic studies of Reye syndrome performed for two consecutive years in Ohio and in Michigan were reported (Morbidity Mortality Weekly Rep 29:532, 1980). These studies demonstrated an association of Reye syndrome with the administration of aspirin during the antecedent illness. In December 1980, a full report of a small study of Reye syndrome in Arizona by Starko and colleagues (Pediatrics 66:859, 1980) produced similar results. The membership was made aware of these studies by the Committee on Infectious Diseases and the Committee on Drugs via News & Comment in March 1981.

More recently the Committee has had an opportunity to review full reports of the Ohio and Michigan studies, not yet published. The Committee believes that the results of this review should be brought to the attention of the membership.

Each of these studies, including that from Arizona, was performed using the case-control method.




This article has been cited by other articles:


Home page
 BMJHome page
G. H Guyatt, A. D Oxman, G. E Vist, R. Kunz, Y. Falck-Ytter, P. Alonso-Coello, H. J Schunemann, and for the GRADE Working Group
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
BMJ, April 26, 2008; 336(7650): 924 - 926.
[Full Text] [PDF]

Home page
 The Annals of PharmacotherapyHome page
R. D Goldman, K. Ko, L. J Linett, and D. Scolnik
Antipyretic Efficacy and Safety of Ibuprofen and Acetaminophen in Children
Ann. Pharmacother., January 1, 2004; 38(1): 146 - 150.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
C. Rocholl, K. Gerber, J. Daly, A. T. Pavia, and C. L. Byington
Adenoviral Infections in Children: The Impact of Rapid Diagnosis
Pediatrics, January 1, 2004; 113(1): e51 - 56.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Perez-G., M. Melo, A. D. Keegan, and J. Zamorano
Aspirin and Salicylates Inhibit the IL-4- and IL-13-Induced Activation of STAT6
J. Immunol., February 1, 2002; 168(3): 1428 - 1434.
[Abstract] [Full Text] [PDF]

Home page
 CLIN PEDIATRHome page
A. Wong, A. Sibbald, F. Ferrero, M. Plager, M. E. Santolaya, A. M. Escobar, S. Campos, S. Barragan, M. De Leon Gonzalez, G. L. Kesselring, et al.
Antipyretic Effects of Dipyrone Versus Ibuprofen Versus Acetaminophen in Children: Results of a Multinational, Randomized, Modified Double-Blind Study
Clinical Pediatrics, June 1, 2001; 40(6): 313 - 324.
[Abstract] [PDF]

Home page
 PediatricsHome page
R. E. Kauffman
Reye's Syndrome and Salicylate Use, by Karen M. Starko, MD, et al, Pediatrics, 1980;66:859-864; and National Patterns of Aspirin Use and Reye Syndrome Reporting, United States, 1980 to 1985, by Janet B. Arrowsmith et al, Pediatrics, 1987;79:858-863
Pediatrics, July 1, 1998; 102(1): 259 - 262.
[Full Text]

Home page
 CLIN PEDIATRHome page
M. Ipp and D. Jaffe
Physicians' Attitudes Toward the Diagnosis And Management of Fever in Children 3 Months to 2 Years of Age
Clinical Pediatrics, February 1, 1993; 32(2): 66 - 70.
[Abstract] [PDF]