Congenital Rubella and Myxedema
1 The Brookdale Hospital Medical Center, Department of Pediatrics, State University of New York, Downstate Medical Center, Brooklyn, New York
Thyroid disorders have been reported following congenital rubella: four cases of thyroiditis1-4 and two patients with thyrotoxicosis5,6 are known. We report a patient with childhood myxedema and congenital rubella, and indicate that myxedema may occur as a sequela to rubella. This combination of disorders should be added to thyroiditis,5 hypopituitarism7 and adrenal insufficiency4 in the spectrum of possible late diabetes mellitus complications of the congenital rubella syndrome. Patients with congenital rubella should be tested periodically for these endocrine deficiencies.
CASE REPORT
An 8[unknown]-year-old white girl was the product of a seven-month gestation complicated by maternal rubella in the first trimester. Birth weight was 1 kg.
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H. Devos, C. Rodd, N. Gagné, R. Laframboise, and G. Van Vliet A Search for the Possible Molecular Mechanisms of Thyroid Dysgenesis: Sex Ratios and Associated Malformations J. Clin. Endocrinol. Metab., July 1, 1999; 84(7): 2502 - 2506. [Abstract] [Full Text] |
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