PEDIATRICS Vol. 69 No. 3 March 1982, pp. 371-373
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Carboxyhemoglobin Concentration in Fetal Cord Blood and in Blood of Mothers Who Smoked During Labor

M. A. Bureau MD1, J. Monette 1, D. Shapcott PhD1, C. Paré MD1, J. -L. Mathieu MD1, J. Lippé MD1, D. Blovin MD1, Y. Berthiaume 1, and R. Bégin MD1

1 Department of Pediatrics and Obstetrics, Université de Sherbrooke, Sherbrooke, Québec, Canada

It has been established beyond doubt that maternal cigarette smoking is associated with increased perinatal morbidity (prematurity, failure to grow, vaginal bleeding of pregnancy) and perinatal mortality (abortion and fetal or neonatal death).1,2 Various mechanisms have been implicated to explain these adverse effects of maternal smoking on the fetal outcome and among these, chronic carbon monoxide intoxication of the fetus induced by maternal smoking is identified as a major cause of the fetal toxicity of smoking.3,4 In animal studies, chronic exposure to a low level of carbon monoxide produced perinatal complications similar to those reported in pregnant smokers,1,3,4 In humans, accidental carbon monoxide poisoning from sources other than smoking caused fetal death or fetal brain damage.5




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A. GRUSLIN, S. L. PERKINS, R. MANCHANDA, N. FLEMING, and J. J. CLINCH
Maternal Smoking and Fetal Erythropoietin Levels
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