PEDIATRICS Vol. 69 No. 3 March 1982, pp. 277-281
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Interlaboratory Bilirubin Variability

Richard L. Schreiner MD1 and Melvin R. Glick PhD1

1 Departments of Pediatrics and Pathology, Indiana University School of Medicine and James Whitcomb Riley Hospital for Children, Indianapolis

Stabilized liquid quality control sera, some with elevated bilirubin concentrations, were distributed to laboratories for total and conjugated (direct) bilirubin analyses. Interlaboratory variability was high; for example, results ranged from 10.9 to 24.0 mg/100 ml for a serum with a mean bilirubin concentration of 18.1 mg/ 100 ml. Coefficients of variation were typically 10% to 12% for total bilirubin and approximately 24% for conjugated bilirubin analyses. It is believed that these stabilized sera, when used as quality control materials, can help reduce the unacceptably large interlaboratory variability found in this study.

Submitted on June 3, 1981
Accepted on July 27, 1981




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