PEDIATRICS Vol. 69 No. 3 March 1982, pp. 255-259
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Entry of Bilirubin into the Brain Due to Opening of the Blood-Brain Barrier

Rodney L. Levine MD1, Wendy R. Fredericks AB1, and Stanley I. Rapoport MD1

1 Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, Bethesda, Maryland, and Laboratory of Neurosciences, National Institute on Aging, Baltimore

A potential animal model of kernicterus has been developed. The blood-brain barrier was opened on one side of the brain, by brief infusion of a hypertonic solution into the carotid artery. Upon peripheral infusion of bilirubin, the animals developed unilateral yellow staining of the brain: the treated side was stained whereas the control side was not. This cerebral icterus resulted from the entry of albumin-bound bilirubin into the brain, and not from the passage of free bilirubin.

Submitted on June 16, 1981
Accepted on October 6, 1981




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