PEDIATRICS Vol. 69 No. 2 February 1982, pp. 202-203
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Severe Cardiac and Ophthalmologic Malformations in an Infant Exposed to Diphenylhydantoin in Utero

Louis E. Bartoshesky MD, MPH1, Ina Bhan MD1, Kanta Nagpaul MD1, and Hermine Pashayan MD1

1 Center for Birth Defect Evaluation and Division of Pediatric Cardiology, Department of Pediatrics, and Department of Pathology, Tufts-New England Medical Center, Boston

A newborn male infant with multiple congenital malformations including lethal cardiac malformations and severe ophthalmic malformations is described. The infant was exposed in utero to hydantoin. There is no other identifiable cause for the malformations apparent in the infant's or his family's history.

Submitted on January 19, 1981
Accepted on March 30, 1981




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B. S. Carter and J. M. Stewart
Valproic Acid Prenatal Exposure: Association With Lipomyelomeningocele
Clinical Pediatrics, February 1, 1989; 28(2): 81 - 85.
[Abstract] [PDF]