PEDIATRICS Vol. 68 No. 5 November 1981, pp. 650-660
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Nature and Rates of Adverse Reactions Associated with DTP and DT Immunizations in Infants and Children

Christopher L. Cody MD1, Larry J. Baraff MD1, James D. Cherry MD1, S. Michael Marcy MD1, and Charles R. Manclark PhD1

1 Department of Pediatrics, UCLA School of Medicine, Center for the Health Sciences, Los Angeles; Department of Pediatrics, Kaiser Permanente Medical Group, Los Angeles; and Bureau of Biologics, Food and Drug Administration, Bethesda, Maryland

In 784 DT and 15,752 DTP immunizations given to children 0 to 6 years of age who were prospectively studied for reactions occurring within 48 hours following immunization, minor reactions were significantly more frequent following DTP vaccine. The ratio of reaction rates associated with DTP and DT immunizations (DTP/DT) for selected local and systemic reactions was as follows: local redness, 37.4%/7.6%; local swelling, 40.7%/7.6%; pain, 50.9%/9.9%; fever, 31.5%/14.9%; drowsiness, 31.5%/14.9%; fretfulness, 53.4%/22.6%; vomiting, 6.2%/2.6%; anorexia, 20.9%/7.0% and persistent crying, 3.1%/0.7%. Following DTP immunization nine children developed convulsions and nine developed hypotonic hyporesponsive episodes. No sequelae were detected following these reactions.

Submitted on December 8, 1980
Accepted on February 3, 1980




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