PEDIATRICS Vol. 68 No. 5 November 1981, pp. 619-622
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Pharmacologic Compliance with Antibiotic Therapy for Acute Otitis Media: Influence on Subsequent Middle Ear Effusion

Richard H. Schwartz MD1, William J. Rodriquez MD, PhD1, and Kenneth M. Grundfast MD1

1 Research Foundation, Microbiology Research, Children's Hospital National Medical Center, Washington, DC

The frequency of otitis media with effusion (serous otitis media, secretory otitis media) detected after conventional antibiotic treatment of acute otitis media is approximately 50%. The relationship between pharmacologic compliance and the frequency of otitis media with effusion was studied. A Micrococcus lutea bioinhibition test was used to detect the presence of substances in the urine that inhibited the growth of this antibiotic-sensitive organism. On the fourth, seventh, and tenth days of antibiotic treatment for acute otitis media urine specimens were collected. Otitis media with effusion was detected in 53% of 66 children who had positive results for M lutea bioinhibition compliance tests for all three urine specimens. Electro-acoustic impedance measurements (tympanograms) confirmed the presence of effusion in all children in the effusion group tested by this method. The M lutea bioinhibition assay is a practical, in-office method to validate periodically, during treatment, pharmacologic compliance with antibiotics used for treatment of acute otitis media.

Submitted on September 5, 1980
Accepted on February 11, 1981




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