PEDIATRICS Vol. 68 No. 3 September 1981, pp. 349-353
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by David, R.
Right arrow Articles by Gartner, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by David, R.
Right arrow Articles by Gartner, J. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Water Intoxication in Normal Infants: Role of Antidiuretic Hormone in Pathogenesis

Ronald David MD1, Demetrius Ellis MD1, and J. Carlton Gartner MD1

1 Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh

Eight infants, 2 to 5 months of age, who were seen with somnolence or irritability, seizures, and hypothermia are described. The symptoms developed following the ingestion of dilute formula. All infants were hyponatremic. Three patients were identified by the symptom complex and were evaluated prior to any therapeutic intervention. Plasma arginine vasopressin concentration and urinary osmolality were either normal or increased despite hyponatremia and decreased serum osmolality. These data, coupled with rapid biochemical and clinical improvement following fluid restriction and/or administration of 3% NaCl, strongly implicate the excessive release of arginine vasopressin in the pathogenesis of this syndrome of water intoxication.

Submitted on October 27, 1980
Accepted on December 31, 1980


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 CLIN PEDIATRHome page
J. S. Baird
Extreme Hyponatremia in a Child With Vegetative State and Water Intoxication
Clinical Pediatrics, September 1, 2009; 48(7): 767 - 769.
[PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Baum
Postnatal developmental renal physiology: a study of historic significance
Am J Physiol Renal Physiol, April 1, 2009; 296(4): F667 - F668.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
P Bhalla, F E Eaton, J B S Coulter, F L Amegavie, J A Sills, and L J Abernethy
Lesson of the week: Hyponatraemic seizures and excessive intake of hypotonic fluids in young children
BMJ, December 11, 1999; 319(7224): 1554 - 1557.
[Full Text]

Home page
 PediatricsHome page
A. I. Arieff and B. A. Kronlund
Fatal Child Abuse by Forced Water Intoxication
Pediatrics, June 1, 1999; 103(6): 1292 - 1295.
[Abstract] [Full Text]

Home page
 Circ. Res.Home page
E. Kozniewska, T. P. L. Roberts, Z. S. Vexler, M. Oseka, J. Kucharczyk, and A. I. Arieff
Hormonal Dependence of the Effects of Metabolic Encephalopathy on Cerebral Perfusion and Oxygen Utilization in the Rat
Circ. Res., April 1, 1995; 76(4): 551 - 558.
[Abstract] [Full Text]

Home page
 CLIN PEDIATRHome page
Z. Horev and A. H. Cohen
Compulsive Water Drinking in Infants and Young Children
Clinical Pediatrics, April 1, 1994; 33(4): 209 - 213.
[Abstract] [PDF]

Home page
 Arch Fam MedHome page
R. E. Sharf
Seizure From Hyponatremia in Infants: Early Recognition and Treatment
Arch Fam Med, June 1, 1993; 2(6): 647 - 652.
[Abstract] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
J. P. Keating, G. J. Schears, and P. R. Dodge
Oral Water Intoxication in Infants: An American Epidemic
Arch Pediatr Adolesc Med, September 1, 1991; 145(9): 985 - 990.
[Abstract] [PDF]

Home page
 CLIN PEDIATRHome page
P. Accardo, J. Caul, and B. Whitman
Excessive Water Drinking: A Marker of Caretaker Interaction Disturbance
Clinical Pediatrics, September 1, 1989; 28(9): 416 - 418.
[Abstract] [PDF]