PEDIATRICS Vol. 67 No. 6 June 1981, pp. 876-878
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Plasma Concentrations of Isoniazid in Children with Tuberculous Infections

William A. Olson PhD1, Albert W. Pruitt MD1, and Peter G. Dayton DSc1

1 Departments of Pediatrics, Medicine and Pharmacology, Emory University School of Medicine, Atlanta

Six children with tuberculous infection were given their daily prescribed doses of isoniazid by the oral and the intramuscular route on different days. The plasma concentrations reached after both routes of administration were nearly equivalent. The plasma half-life of isoniazid ranged from 1.6 to 4.8 hours. The observed plasma concentrations in these children were higher than those reported in many adults. This difference is due to the larger doses of isoniazid prescribed for children.

Submitted on June 2, 1980
Accepted on September 2, 1980