PEDIATRICS Vol. 67 No. 5 May 1981, pp. 727-728
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Development of Meningitis During Therapy with Cefamandole

S. C. Aronoff MD1, W. Thomford MD1, J. S. Bertino PharmD1, and W. T. Speck MD1

1 Department of Pediatrics, Rainbow Babies and Childrens Hospital, Case Western Reserve University, Cleveland

Cefamandole nafate is a relatively new cephalosporin approved for use in pediatric patients. This compound offers certain advantages over previously approved cephalosporins including its in vitro antimicrobial activity against beta-lactamase-producing Haemophilus influenzae. The purpose of this report is to describe a potential hazard associated with the use of this and closely related antimicrobial agents in life-threatening bacterial infections.

CASE REPORT

This was the first Rainbow Babies and Childrens Hospital admission for this 7-month-old boy with a ten-day history of fever and irritability. Seven days prior to admission he was seen by a local physician for fever. No source of infection was noted and the infant was treated with 300,000 units of intramuscular procaine penicillin.




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M. T. Brady, W. J. Barson, H. J. Cannon JR, and L. K. Grossman
Onset of Hemophilus influenzae Type-b Meningitis During Cefaclor Therapy for Preseptal Cellulitis
Clinical Pediatrics, March 1, 1987; 26(3): 132 - 134.
[Abstract] [PDF]