Reye's Syndrome and Salicylate Use
1 Field Services Division, Bureau of Epidemiology, Center for Disease Control, Atlanta; Departments of Pathology and Pediatrics, University of Arizona, College of Medicine, Tucson; and Bureau of Epidemiology and Laboratory Services, Division of Disease Control Services, Arizona Department of Health Services, Phoenix
During an outbreak of influenza A, seven patients with Reye's syndrome and 16 ill classmate control subjects were evaluated for characteristics of the patients' prodromal illness and the control subjects illness and for medication usage. Patients during the prodrome and control subjects had similar rates of sore throat, coryza, cough, headache, and gastrointestinal complaints except for documented fever which occurred significantly more often in patients than in control subjects (P = .05). While medications which did not contain salicylate were taken as frequently by patients as control subjects, patients took more salicylate-containing medications than did control children (P < .01). All seven patients took salicylate whereas only eight of 16 control subjects did so (P < .05). Patients took larger doses of salicylate than did the entire control group (P < .01). When the eight control subjects who took salicylate were compared with the patients, the patients still tended to take larger doses (P = .08). Patients with fever took salicylate more frequently than control subjects with fever (P < .01). In addition, salicylate consumption was correlated with severity of Reye's syndrome (P < .05). It is postulated that salicylate, operating in a dose-dependent manner, possibly potentiated by fever, represents a primary causative agent of Reye's syndrome.
Submitted on March 21, 1980Accepted on May 9, 1980
CiteULike 
Connotea 
Del.icio.us 
Digg 
Facebook 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  P. Monagle, E. Chalmers, A. Chan, G. deVeber, F. Kirkham, P. Massicotte, and A. D. Michelson Antithrombotic Therapy in Neonates and Children: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) Chest, June 1, 2008; 133(6_suppl): 887S - 968S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-i. Kawada, H. Kimura, Y. Kamachi, K. Nishikawa, M. Taniguchi, K. Nagaoka, H. Kurahashi, S. Kojima, and T. Morishima Analysis of gene-expression profiles by oligonucleotide microarray in children with influenza J. Gen. Virol., June 1, 2006; 87(6): 1677 - 1683. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Battaglia, M. Salvi, and A. Toninello Oxidative Stress Is Responsible for Mitochondrial Permeability Transition Induction by Salicylate in Liver Mitochondria J. Biol. Chem., October 7, 2005; 280(40): 33864 - 33872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Monagle, A. Chan, P. Massicotte, E. Chalmers, and A. D. Michelson Antithrombotic Therapy in Children*: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy Chest, September 1, 2004; 126(3_suppl): 645S - 687S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Clarkson and I Choonara Surveillance for fatal suspected adverse drug reactions in the UK Arch. Dis. Child., December 1, 2002; 87(6): 462 - 466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. Ray Evidence in Upheaval: Incorporating Observational Data Into Clinical Practice Arch Intern Med, February 11, 2002; 162(3): 249 - 254. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Wong, A. Sibbald, F. Ferrero, M. Plager, M. E. Santolaya, A. M. Escobar, S. Campos, S. Barragan, M. De Leon Gonzalez, G. L. Kesselring, et al. Antipyretic Effects of Dipyrone Versus Ibuprofen Versus Acetaminophen in Children: Results of a Multinational, Randomized, Modified Double-Blind Study Clinical Pediatrics, June 1, 2001; 40(6): 313 - 324. [Abstract] [PDF]
|
|
|
|
|
|
P. Monagle, A. D. Michelson, E. Bovill, and M. Andrew Antithrombotic Therapy in Children Chest, January 1, 2001; 119 (2009): 344S - 370S. [Full Text] [PDF]
|
|
|
|
|
|
M. J. Prior, E. B. Nelson, and A. R. Temple Pediatric Ibuprofen Use Increases While Incidence of Reye's Syndrome Continues to Decline Clinical Pediatrics, April 1, 2000; 39(4): 245 - 247. [PDF]
|
|
|
|
 |
|
 S. M. Hall, R. Lynn, G. M. Johnson, E. D. Belay, L. B. Schonberger, and A. S. Monto Reye's Syndrome N. Engl. J. Med., September 9, 1999; 341(11): 845 - 847. [Full Text]
|
|
|
|
|
|
E. D. Belay, J. S. Bresee, R. C. Holman, A. S. Khan, A. Shahriari, and L. B. Schonberger Reye's Syndrome in the United States from 1981 through 1997 N. Engl. J. Med., May 6, 1999; 340(18): 1377 - 1382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Monto The Disappearance of Reye's Syndrome -- A Public Health Triumph N. Engl. J. Med., May 6, 1999; 340(18): 1423 - 1424. [Full Text]
|
|
|
|
 |
|
 H. A. Pearson The Ever-changing Content of Pediatrics Over Fifty Years Pediatrics, July 1, 1998; 102(1): 168 - 176. [Full Text]
|
|
|
|
|
|
R. E. Kauffman Reye's Syndrome and Salicylate Use, by Karen M. Starko, MD, et al, Pediatrics, 1980;66:859-864; and National Patterns of Aspirin Use and Reye Syndrome Reporting, United States, 1980 to 1985, by Janet B. Arrowsmith et al, Pediatrics, 1987;79:858-863 Pediatrics, July 1, 1998; 102(1): 259 - 262. [Full Text]
|
|
|
|
|
|
I CHOONARA and J DUNNE Licensing of medicines Arch. Dis. Child., May 1, 1998; 78(5): 402 - 403. [Full Text]
|
|
|
|
 |
|
 C. B. Lindsley Uses of Nonsteroidal Anti-inflammatory Drugs in Pediatrics Arch Pediatr Adolesc Med, February 1, 1993; 147(2): 229 - 236. [Abstract] [PDF]
|
|
|
|
 |
|
 Reye Syndrome Surveillance--United States, 1989 JAMA, February 27, 1991; 265(8): 960 - 960. [PDF]
|
|
|
|
|
|
Reye Syndrome Surveillance-- United States, 1987 and 1988 JAMA, June 23, 1989; 261(24): 3520 - 3523. [PDF]
|
|
|
|
|
|
B. W. Forsyth, R. I. Horwitz, D. Acampora, E. D. Shapiro, C. M. Viscoli, A. R. Feinstein, R. Henner, N. B. Holabird, B. A. Jones, A. D. E. Karabelas, et al. New Epidemiologic Evidence Confirming That Bias Does Not Explain the Aspirin/Reye's Syndrome Association JAMA, May 5, 1989; 261(17): 2517 - 2524. [Abstract] [PDF]
|
|
|
|
|
|
E. S. Hurwitz The Changing Epidemiology of Reye's Syndrome in the United States: Further Evidence for a Public Health Success JAMA, December 2, 1988; 260(21): 3178 - 3180. [Abstract] [PDF]
|
|
|
|
|
|
P. F. Pinsky, E. S. Hurwitz, L. B. Schonberger, and W. J. Gunn Reye's Syndrome and Aspirin: Evidence for a Dose-Response Effect JAMA, August 5, 1988; 260(5): 657 - 661. [Abstract] [PDF]
|
|
|
|
|
|
E. S. Hurwitz, M. J. Barrett, D. Bregman, W. J. Gunn, P. Pinsky, L. B. Schonberger, J. S. Drage, R. A. Kaslow, D. B. Burlington, G. V. Quinnan, et al. Public Health Service Study of Reye's Syndrome and Medications: Report of the Main Study JAMA, April 10, 1987; 257(14): 1905 - 1911. [Abstract] [PDF]
|
|
|
|
|
|
F. J. Holtzhauer, R. J. Campbell, L. J. Hall, and T. J. Halpin Reye's Syndrome: An Epidemiologic Analysis of Mild Disease Arch Pediatr Adolesc Med, December 1, 1986; 140(12): 1231 - 1236. [Abstract] [PDF]
|
|
|
|
 |
|
 R. Glass New prospects for epidemiologic investigations Science, November 21, 1986; 234(4779): 951 - 955. [Abstract] [PDF]
|
|
|
|
|
|
H. J. Bonnell and J. B. Beckwith Fatty Liver in Sudden Childhood Death: Implications for Reye's Syndrome? Arch Pediatr Adolesc Med, January 1, 1986; 140(1): 30 - 33. [Abstract] [PDF]
|
|
|
|
|
|
P. L. Remington, C. L. Shabino, H. McGee, G. Preston, A. P. Sarniak, and W. N. Hall Reye Syndrome and Juvenile Rheumatoid Arthritis in Michigan Arch Pediatr Adolesc Med, September 1, 1985; 139(9): 870 - 872. [Abstract] [PDF]
|
|
|
|
|
|
J. P. Taylor, T. L. Gustafson, C. C. Johnson, N. Brandenburg, and W. P. Glezen Antipyretic Use Among Children During the 1983 Influenza Season Arch Pediatr Adolesc Med, May 1, 1985; 139(5): 486 - 488. [Abstract] [PDF]
|
|
|
|
|
|
Leads from the MMWR JAMA, February 8, 1985; 253(6): 751 - 753. [PDF]
|
|
|
|
|
|
R. I. Horwitz, A. R. Feinstein, and M. R. Harvey Case-Control Research: Temporal Precedence and Other Problems of the Exposure-Disease Relationship Arch Intern Med, June 1, 1984; 144(6): 1257 - 1259. [Abstract] [PDF]
|
|
|
|
|
|
K You Salicylate and mitochondrial injury in Reye's syndrome Science, July 8, 1983; 221(4606): 163 - 165. [Abstract] [PDF]
|
|
|
|
|
|
S. R. Daniels, R. S. Greenberg, and M. A. Ibrahim Scientific Uncertainties in the Studies of Salicylate Use and Reye's Syndrome JAMA, March 11, 1983; 249(10): 1311 - 1316. [Abstract] [PDF]
|
|
|
|
 |
|
 Infectious Diseases: An Annotated Bibliography of Recent Literature: References to Journal Articles and Other Papers Ann Intern Med, December 1, 1982; 97(6): 938 - 943. [Abstract] [PDF]
|
|
|
|
|
|
W. P. GLEZEN Aspirin and Reye's Syndrome Arch Pediatr Adolesc Med, November 1, 1982; 136(11): 971 - 972. [Abstract] [PDF]
|
|
|
|
|
|
R. A. HOEKELMAN Take Two Aspirin and Call Me in the Morning: Salicylate Use and Reye's Syndrome Arch Pediatr Adolesc Med, November 1, 1982; 136(11): 973 - 974. [Abstract] [PDF]
|
|
|
|
|
|
T. J. Halpin, F. J. Holtzhauer, R. J. Campbell, L. J. Hall, A. Correa-Villasenor, R. Lanese, J. Rice, and E. S. Hurwitz Reye's Syndrome and Medication Use JAMA, August 13, 1982; 248(6): 687 - 691. [Abstract] [PDF]
|
|
|
|
|
|
E. R. Alexander Salicylates and Reye's Syndrome: Epidemiologic Data as a Basis of Action JAMA, August 13, 1982; 248(6): 722 - 723. [Abstract] [PDF]
|
|
|
|
|
|
R. J. Waldman, W. N. Hall, H. McGee, and G. Van Amburg Aspirin as a Risk Factor in Reye's Syndrome JAMA, June 11, 1982; 247(22): 3089 - 3094. [Abstract] [PDF]
|
|
|
|
|
|
D. M. Volk Clinical Review : Reye's Syndrome: An Update for the Practicing Physician Clinical Pediatrics, August 1, 1981; 20(8): 505 - 511. [PDF]
|
|
