PEDIATRICS Vol. 66 No. 5 November 1980, pp. 789-791
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Acrodermatitis Enteropathica: Zinc Levels and Cell-Mediated Immunity

R. K. Chandra MD, FRCP(C)1

1 Janeway Child Health, St Johns, Newfoundland, Canada

Acrodermatitis enteropathica (AE) is a rare vesicobullous skin disorder.1 Genealogic data suggest an autosomal recessive mode of inheritance. The onset of symptoms is generally insidious. In breastfed infants, the disorder may be precipitated on weaning to cow's milk. The frequent occurrence of secondary infections, particularly with opportunistic fungi and bacteria, led to the suspicion that AE is associated with immunodeficiency. "Dysgammaglobulinemia" has been reported in one infant2 and defective chemotaxis in another three patients.3 Limited autopsy observations showed atrophic thymus, tonsils, germinal centers, and Peyer patches.2,4 We report variable impairment of cell-mediated immunity in ten patients with AE of whom eight had low plasma zinc levels.


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