PEDIATRICS Vol. 66 No. 5 November 1980, pp. 789-791
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chandra, R. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chandra, R. K.

Acrodermatitis Enteropathica: Zinc Levels and Cell-Mediated Immunity

R. K. Chandra MD, FRCP(C)1

1 Janeway Child Health, St Johns, Newfoundland, Canada

Acrodermatitis enteropathica (AE) is a rare vesicobullous skin disorder.1 Genealogic data suggest an autosomal recessive mode of inheritance. The onset of symptoms is generally insidious. In breastfed infants, the disorder may be precipitated on weaning to cow's milk. The frequent occurrence of secondary infections, particularly with opportunistic fungi and bacteria, led to the suspicion that AE is associated with immunodeficiency. "Dysgammaglobulinemia" has been reported in one infant2 and defective chemotaxis in another three patients.3 Limited autopsy observations showed atrophic thymus, tonsils, germinal centers, and Peyer patches.2,4 We report variable impairment of cell-mediated immunity in ten patients with AE of whom eight had low plasma zinc levels.




This article has been cited by other articles:


Home page
 J. Nutr.Home page
M. K. Baum, G. Shor-Posner, and A. Campa
Zinc Status in Human Immunodeficiency Virus Infection
J. Nutr., May 1, 2000; 130(5): 1421S - 1423.
[Abstract] [Full Text]

Home page
 J. Nutr.Home page
E. Mocchegiani and M. Muzzioli
Therapeutic Application of Zinc in Human Immunodeficiency Virus against Opportunistic Infections
J. Nutr., May 1, 2000; 130(5): 1424S - 1431.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. K. Chandra
Nutrition, immunity and infection: From basic knowledge of dietary manipulation of immune responses to practical application of ameliorating suffering and improving survival
PNAS, December 10, 1996; 93(25): 14304 - 14307.
[Full Text] [PDF]