PEDIATRICS Vol. 66 No. 5 November 1980, pp. 716-719
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Wilms Tumor in Five Cousins

José F. Cordero MD1, Frederick P. Li MD1, Lewis B. Holmes MD1, and Park S. Gerald MD1

1 Center for Human Genetics, Massachusetts General Hospital and Children's Hospital Medical Center, and Division of Epidemiology and Biostatistics, Sidney Farber Cancer Institute, Harvard Medical School, and Clinical Studies Section, National Cancer Institute, Boston

Wilms tumor developed in five cousins in a family. Two with bilateral tumors have died, but three with unilateral lesions have survived. None of the patients had associated chromosome defects, aniridia, hemihypertrophy, or other anomalies. The pattern of Wilms tumor in the family is consistent with several postulated mechanisms of inheritance of the neoplasm, and shows that relatives within affected families may be at risk.

Submitted on December 14, 1979
Accepted on February 25, 1980