PEDIATRICS Vol. 66 No. 4 October 1980, pp. 526-531
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The Immotile Cilia Syndrome: A Cause of Recurrent Pulmonary Disease in Children

Anthony R. Rooklin MD1, Stephen J. McGeady MD1, Diran O. Mikaelian MD1, Raymond Z. Soriano MD1, and Herbert C. Mansmann Jr MD1

1 Departments of Pediatrics, Pathology, and Otolaryngology of the Jefferson Medical College of Thomas Jefferson University and The Children's Heart Hospital, Philadelphia

Immotile cilia syndrome was diagnosed in two male siblings, aged 32 months and 5 years, who had recurrent pneumonia, wheezing, and bronchitis. The youngest child had recurrent atelectasis, chronic sinusitis, recurrent otitis media, and failure to thrive. Neither child had situs inversus. Electron micrographs done on nasal mucosal biopsies revealed absent dynein arms. Symptoms were controlled in the younger brother by using daily antihistamine-decongestant and bronchodilator therapy. The immotile cilia syndrome must be considered in children before labeling chronic respiratory disease as idiopathic.

Submitted on October 15, 1979
Accepted on March 7, 1980




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