PEDIATRICS Vol. 66 No. 3 September 1980, pp. 468-469
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Noonan's Syndrome: A Historical Perspective

Roger B. Cole MD1

1 The Willis J. Potts Children's Heart Center (Division of Cardiology), The Children's Memorial Hospital, and Department of Pediatrics, Northwestern University Medical School, Chicago

Pediatrics and fine art do not often cross paths, but such an example seems to have occurred with Noonan's (pseudo-Turner's) syndrome and a famous painting by Ivan Le Lorraine Albright.

In 1968 Noonan first described the syndrome that bears her name.1 These patients have characteristic facies: ptosis, antimongoloid palpebral slant, broad flat nose, webbed neck, as well as a high arched palate and malformed ears. They are usually of short stature and frequently have congenital heart disease, most often pulmonic stenosis secondary to a dysplastic valve with or without an associated shunt at the atrial level. Pectus excavatum, cubitus valgus, undescended testes, and impaired mental development are commonly found.