PEDIATRICS Vol. 66 No. 3 September 1980, pp. 438-444
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Follow-up Studies of Very Low Birth Weight Infants (1,250 Grams or Less) Born and Treated Within a Perinatal Center

Savitri P. Kumar MD1, Endla K. Anday MD1, Linda M. Sacks MD1, Rosalind V. Ting MD, MPH1, and Maria Delivoria-Papadopoulos MD1

1 Department of Pediatrics, University of Pennsylvania School of Medicine, Divisions of Neonatology and Child Development, Philadelphia

The growth and development of inborn very low birth weight infants was evaluated in 50 of 60 survivors from 132 babies weighing le1,250 gm born July 1974 to December 1977. Mean ± SE birth weight and gestation was 1,066 ± 19.3 gm and 29.5 ± 0.3 weeks, respectively, with 13 infants small-for-gestational age. Of the survivors, 26% weighed le1,000 gm. Male to female ratio was 1:1.4. Apgar scores le5 at five minutes occurred in 16% of the infants. Respiratory distress syndrome occurred in 56%, but only 10% (5/50) required mechanical ventilation. At 1 year, 46% small for gestational age (SGA) and 8% appropriate for gestational age (AGA) infants were less than the third percentile for weight. Major neurologic abnormality occurred in three infants (6%), one of whom is also blind. Grade V retrolental fibroplasia occurred in two others. Severe developmental delay (development quotient <80, Gesell) occurred in these five infants and two other neurologically normal babies. Of 15 infants weighing le1,000 gm, two had major handicaps. Eight percent of the AGA infants and 30% of the SGA infants had major handicaps. These data indicate that infants born and treated in a perinatal center have a decreased incidence of asphyxia and severe respiratory distress syndrome and that the incidence of major handicaps is reduced, especially in the appropriate for gestational age baby.

Submitted on December 14, 1979
Accepted on February 28, 1980




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M. Oishi, H. Nishida, and T. Sasaki
Japanese Experience With Micropremies Weighing Less Than 600 Grams Born Between 1984 to 1993
Pediatrics, June 1, 1997; 99(6): e7 - e7.
[Abstract] [Full Text] [PDF]