PEDIATRICS Vol. 66 No. 2 August 1980, pp. 205-214
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Sudden Infant Death Syndrome: Sleep Apnea and Respiration in Subsequent Siblings

Toke Hoppenbrouwers PhD1, Joan E. Hodgman MD1, Dennis McGinty PhD1, R. M. Harper PhD1, and M. B. Sterman PhD1

1 Newborn Division of the Los Angeles County-University of Southern California Medical Center; Department of Pediatrics, University of Southern California School of Medicine; Sepulveda Veterans Hospital; Departments of Anatomy, Psychiatry, and the Brain Research Institute, University of California, Los Angeles

Subsequent siblings of infants who died of the Sudden Infant Death Syndrome are at a four- to six-times increased risk to die of this syndrome. This study compares the respiratory development during sleep state of this epidemiologic high risk group with that of normal infants during the first six months of life. Subsequent siblings exhibited higher respiratory rates in all states at 3 months of age. Quiet sleep and indeterminate respiratory rates were elevated at 1 week of age compared to control infants. Indeterminate respiratory rates remained higher at 6 months of age. These differences were accompanied by a reduced incidence of total breathing pauses of two to five seconds and six to nine seconds duration in siblings. Study groups could not be differentiated on the basis of either breathing pauses of more than ten seconds or central apnea of six seconds or more. Obstructive and mixed apnea (6 seconds or more) were infrequently observed in these study groups. A high degree of intersubject variability characterized all data on breathing pauses.

Submitted on August 24, 1979
Accepted on November 29, 1979




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