PEDIATRICS Vol. 66 No. 1 July 1980, pp. 9-13
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Haemophilus influenzae Type b Meningitis: Occurrence in Three Siblings Over a Two-Year Period

Zave H. Chad MDCM1, E. Lee Pearson MD1, Elena R. Reece MD1, and Keith R. Powell MD1

1 Department of Pediatrics, Divisions of Immunology and Infectious Diseases, McGill University School of Medicine, and the Montreal Children's Hospital, Montreal

Haemophilus influenzae type b meningitis occurred in all three siblings in one family over a 24-month period. Investigations of the organisms involved and immunologic studies of the family revealed low percentages of E-rosette-forming cells (T-cells) in both surviving children and in the father. This report suggests that host susceptibility to H influenzae is genetically controlled and that T-cell functions, as yet undetermined, may be involved.

Submitted on August 24, 1979
Accepted on October 23, 1979