PEDIATRICS Vol. 66 No. 1 July 1980, pp. 63-67
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Arulanantham, K.
Right arrow Articles by Gryboski, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Arulanantham, K.
Right arrow Articles by Gryboski, J. D.

The Association of Inflammatory Bowel Disease and X Chromosomal Abnormality

Karunyan Arulanantham MBBS1, Michael S. Kramer MD1, and Joyce D. Gryboski MD1

1 Departments of Pediatrics, Yale University School of Medicine, New Haven, and Newington Children's Hospital, Newington, Connecticut; and the Departments of Pediatrics, Epidemiology and Health, McGill University, Montreal

Five patients with inflammatory bowel disease (IBD) had abnormalities of the X chromosome (the Turner syndrome). Based on the estimated prevalence rate of 1:10,000 live female births for the Turner syndrome and 1:50,000 for IBD, random association of these two conditions would be expected in 1:500 million live female births. Given these odds, the findings in these five patients would suggest a clinical association not based on pure chance and unlikely to be accounted for by Berkson's or other referral bias. It is speculated that abnormal immune mechanism could possibly increase the susceptibility of patients with the Turner syndrome to develop IBD. Both conditions cause growth failure. Awareness of the association has clinical importance in identifying the cause of growth failure in a child with either X chromosomal abnormality or IBD.

Submitted on August 20, 1979
Accepted on October 22, 1979




This article has been cited by other articles:


Home page
 CLIN PEDIATRHome page
B. H. Doswell, J. Visootsak, A. N. Brady, and J. M. Graham Jr
Turner Syndrome: An Update and Review for the Primary Pediatrician
Clinical Pediatrics, May 1, 2006; 45(4): 301 - 313.
[Abstract] [PDF]

Home page
 NEJMHome page
V. P. Sybert and E. McCauley
Turner's Syndrome
N. Engl. J. Med., September 16, 2004; 351(12): 1227 - 1238.
[Full Text] [PDF]

Home page
 Endocr. Rev.Home page
M. Elsheikh, D. B. Dunger, G. S. Conway, and J. A. H. Wass
Turner's Syndrome in Adulthood
Endocr. Rev., February 1, 2002; 23(1): 120 - 140.
[Abstract] [Full Text] [PDF]