PEDIATRICS Vol. 66 No. 1 July 1980, pp. 50-55
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Etiology of Pertussis Syndrome

Margaret A. Keller MD1, Rouben Aftandelians MD1, and James D. Connor MD1

1 Los Angeles County Harbor/UCLA School of Medicine, Los Angeles; the Children's Hospital Medical Center, Tehran, Iran; and the University of California, San Diego

One hundred patients with clinical pertussis were studied to determine the etiology of pertussis syndrome. Forty-two (42%) of the patients had either Bordetella pertussis or Bordetella parapertussis isolated from the nasopharynx. In an additional 36 (36%) patients, B pertussis was isolated from the nasopharynx of the associated index case or family contact case. Thus, Bordetella was isolated from 78 (78%) of the patients or from their immediate family group. Of the 22 culture-negative patients residing in culture-negative families, 12 had serologic evidence of Bordetella infection and another was from a family group in which two members were seropositive. Therefore, 91 patients (91%) had bacteriologic or serologic evidence of Bordetella infection themselves or within their families. Viral cultures were obtained on 75 of the patients. Adenoviruses were isolated from 33% of those with positive cultures for B pertussis and from 14% of those with negative cultures. In the group without direct or indirect, bacteriologic or serologic evidence of Bordetella infection, the adenoviral isolation rate (13%) was not significantly different from the adenoviral isolation rate (33%) in patients with a positive bacterial culture. These data do not support a role for adenovirus alone in causing pertussis syndrome.

Submitted on August 20, 1979
Accepted on October 2, 1979




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D. J. Farrell, G. Daggard, and T. K. S. Mukkur
Nested Duplex PCR To Detect Bordetella pertussis and Bordetella parapertussis and Its Application in Diagnosis of Pertussis in Nonmetropolitan Southeast Queensland, Australia
J. Clin. Microbiol., March 1, 1999; 37(3): 606 - 610.
[Abstract] [Full Text]