Letters to the Editor
1 The Children's Hospital, 1056 East 19th Avenue, Denver, CO 80218
It is an appropriate conclusion that our data should "mitigate enthusiasm for the prospective use of WBC parameters in the diagnosis of infection of the newborn infant." Such enthusiasm for a laboratory test is usually the result of the overzealous interpretation of inadequately controlled comparative studies suffering from small sample size, or inappropriate extrapolation of limited conclusions to expanded populations. Very few diagnostic laboratory tests are so sensitive and specific that they lack significant false-positive or false-negative results, and the aforementioned white blood cell studies are commonly referred to as nonspecific indicators of inflammation with just cause.




