PEDIATRICS Vol. 65 No. 6 June 1980, pp. 1170-1172
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Pulmonary Excretion of Carbon Monoxide in the Human Infant as an Index of Bilirubin Production IV. Effects of Breast-feeding and Caloric Intake in the First Postnatal Week

David K. Stevenson MD1, Albert L. Bartoletti MD1, Clinton R. Ostrander MS1, and John D. Johnson MD1

1 Departments of Pediatrics, Stanford University School of Medicine, Stanford, California, and University of New Mexico School of Medicine, Albuquerque

Measurements of the pulmonary excretion rate of carbon monoxide (VEco) as an index of bilirubin production in the first several days of life were taken from 64 breast-fed or bottle-fed infants. Twenty-one infants (ge37 weeks of gestation) were breast-fed; 43 infants (28 to 42 weeks of gestation) were bottle-fed a commercially prepared formula. Information pertaining to their caloric intake during the 24-hour period preceding VECO determination was taken from 38 of the 43 infants who were bottle-fed and they were placed into three groups based on their caloric intake: (1) le60 kcal/kg/day (19 infants); (2) 61 to 100 kcal/kg/day (7 infants); and (3) > 100 kcal/kg/day (12 infants). There was no significant difference in bilirubin production between bottle-fed and breast-fed infants. No effect of caloric deprivation on bilirubin production was demonstrated. The mean VECO values were 18.5 ± 0.9 (SE) for group 1, 17.7 ± 1.8 (SE) for group 2, and 16.2 ± 1.1 (SE) µl/kg/hr for group 3.




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