PEDIATRICS Vol. 65 No. 5 May 1980, pp. 893-896
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Chronic Vitamin A Intoxication in Infants Fed Chicken Liver

C. Patrick Mahoney MD1, M. Theodore Margolis MD1, Thomas A. Knauss MD1, and Robert F. Labbe PhD1

1 Sections of Pediatric Endocrinology and Neuroradiology, The Mason Clinic; Departments of Neurology, Children's Orthopedic Hospital and Medical Center and Group Health Cooperative of Puget Sound; and Department of Laboratory Medicine, University of Washington Medical School, Seattle

Twin female infants were fed 120 gm of chicken liver homogenate daily for four months. They developed irritability, vomiting, and bulging anterior fontanelles. Computed tomograms of the brain revealed enlarged ventricles in both infants and dilated subarachnoid spaces in one. Plasma vitamin A concentrations were elevated. After all sources of vitamin A intake were stopped, the infants recovered without sequelae. The chicken liver homogenate contained 36,000 IU of vitamin A per 120 gm. Since infants often receive 4,000 units of vitamin A daily from fortified milk and vitamin supplements, they probably cannot be fed 60 gm of chicken liver safely more often than once weekly.

Submitted on May 8, 1979
Accepted on August 10, 1979




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[Abstract] [Full Text] [PDF]