PEDIATRICS Vol. 65 No. 5 May 1980, pp. 1000-1002
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Metopic Craniostenosis as a Consequence of Fetal Head Constraint: Two Interesting Experiments of Nature

John M. Graham Jr MD1 and David W. Smith MD1

1 Dysmorphology Unit, Child Development and Mental Retardation Center, and the Center for Inherited Diseases, Department of Pediatrics, University of Washington School of Medicine, Seattle

Two instances of metopic craniosynostosis provide dramatic experiments of nature which implicate fetal head constraint as one cause of early sutural fusion. The presumed restriction of growth stretch at the metopic suture in one instance was due to a bicornuate uterus in which the fetal head was markedly constrained. The second instance was in one of monozygotic triplets reared in a small mother in which the affected fetal head had been wedged between the hips of the two unaffected siblings.

Submitted on July 19, 1979
Accepted on August 20, 1979




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