PEDIATRICS Vol. 65 No. 4 April 1980, pp. 835-836
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A Randomized Controlled Trial of Prenatal Nutritional Supplementation

Howard N. Jacobson MD1

1 Institute of Nutrition, University of North Carolina, Chapel Hill, North Carolina

This report is the long-awaited presentation of the results of the major study on the use of nutritional supplementation to improve the outcomes of pregnancy. In this study, a nutritional supplement refers to the provision of specified amounts of nutrients in a formula made up as a beverage. The formula would be used to aid in the quantification of the dietary intake of nutrients under study, in this case calories and protein. The expectation was that the supplements would be consumed in addition to the diet normally consumed and that they would not displace foods normally eaten.

The study design was initially presented at a workshop on nutritional supplementation and the outcome of pregnancy and sponsored by the Committee on Maternal Nutrition, National Research Council, in November 1971.1