PEDIATRICS Vol. 65 No. 4 April 1980, pp. 811-814
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Albumin-Collodion Activated Charcoal Hemoperfusion in the Treatment of Severe Theophylline Intoxication in a 3-Year-Old Patient

Thomas M. S. Chang MD, CM, PhD, FRCP(C)1, Enrique Espinosa-Meléndez MD, FRCP(C)1, Thomas E. Francoeur MD, CM1, and Norman R. Eade DPhil, MD, CM1

1 Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, and the Division of Clinical Pharmacology and Toxicology, The Montreal Children's Hospital, Montreal

During treatment for asthma, a 3-year-old, 15-kg child was given 750 mg of theophylline in error. Within three hours she was treated with albumin-collodion activated charcoal (ACAC) hemoperfusion. Immediately before treatment her serum theophylline level was 74 µg/ml. At the end of three hours of hemoperfusion, her theophylline level had fallen to 14.4 µg/ml and four hours later it was 8.8 µg/ml. The ACAC hemoperfusion system completely removed all the theophylline passing through it without saturation, and the total amount of drug removed was 500.8 mg (more than two thirds of the dose administered). The technique described is an efficient and rapidly effective method for the treatment of potentially lethal theophylline intoxication. For maximum effectiveness, it must be instituted as soon after intoxication as possible.

Submitted on June 26, 1979
Accepted on August 8, 1979




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T. M. S. Chang
Artificial Cells as Bioreactive Biomaterials
J Biomater Appl, January 1, 1988; 3(1): 116 - 125.
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