PEDIATRICS Vol. 65 No. 4 April 1980, pp. 683-697
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rush, D.
Right arrow Articles by Susser, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rush, D.
Right arrow Articles by Susser, M.

A Randomized Controlled Trial of Prenatal Nutritional Supplementation in New York City

David Rush MD1, Zena Stein MA, MB, BCh1, and Mervyn Susser MB, BCh, DPH, FRCP(E)1

1 School of Public Health (Epidemiology) the Department of Pediatrics, and the Sergievsky Center, Columbia University, and the New York State Psychiatric Institute, New York

This randomized controlled trial of nutritional supplementation in pregnancy, in a poor black urban population in the United States, aimed to increase the birth weight and influence the postnatal development of the offspring of mothers at high risk of having low birth weight infants. The execution of the research design and adherence to the treatment regimen among the experimental population appeared adequate for a reasonable test of the treatments. At birth, the only significant favorable effect of supplementation observed was the prevention of depressed birth weight among the offspring of mothers who smoked heavily. With balanced protein-calorie supplementation, length of gestation was increased, the proportion of low-birth-weight infants reduced, and mean birth weight raised by 41 gm (not statistically significant). With high protein supplementation, there was an excess of very early premature births and associated neonatal deaths, and there was significant growth retardation up to 37 weeks of gestation. At 1 year of age, significant effects of high protein supplement were found on three psychological measures: visual habituation, visual dishabituation, and mean length of free play episodes. These measures were unrelated to measures of growth at birth and at 1 year of age. There were no detectable residual adverse effects of high protein supplementation at 1 year of age.

Submitted on July 17, 1979
Accepted on July 30, 1979




This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
F. Tofail, L. A. Persson, S. El Arifeen, J. D Hamadani, F. Mehrin, D. Ridout, E.-C. Ekstrom, S. N Huda, and S. M Grantham-McGregor
Effects of prenatal food and micronutrient supplementation on infant development: a randomized trial from the Maternal and Infant Nutrition Interventions, Matlab (MINIMat) study
Am. J. Clinical Nutrition, March 1, 2008; 87(3): 704 - 711.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
A. J. Wilcox
Invited Commentary: The Perils of Birth Weight--A Lesson from Directed Acyclic Graphs
Am. J. Epidemiol., December 1, 2006; 164(11): 1121 - 1123.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
G. M. Chan, K. McElligott, T. McNaught, and G. Gill
Effects of dietary calcium intervention on adolescent mothers and newborns: a randomized controlled trial.
Obstet. Gynecol., September 1, 2006; 108(3): 565 - 571.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
R. Shaheen, A. de Francisco, S. El Arifeen, E.-C. Ekstrom, and L. A. Persson
Effect of prenatal food supplementation on birth weight: an observational study from Bangladesh
Am. J. Clinical Nutrition, June 1, 2006; 83(6): 1355 - 1361.
[Abstract] [Full Text] [PDF]

Home page
 J. Epidemiol. Community HealthHome page
S. Leary, A. Ness, P. Emmett, G. Davey Smith, and ALSPAC Study Team
Maternal diet in pregnancy and offspring height, sitting height, and leg length
J. Epidemiol. Community Health, June 1, 2005; 59(6): 467 - 472.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
I. C. Mcmillen and J. S. Robinson
Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming
Physiol Rev, April 1, 2005; 85(2): 571 - 633.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
Z. A. Bhutta, G. L. Darmstadt, B. S. Hasan, and R. A. Haws
Community-Based Interventions for Improving Perinatal and Neonatal Health Outcomes in Developing Countries: A Review of the Evidence
Pediatrics, February 1, 2005; 115(2/S1): 519 - 617.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
V. M. Moore, M. J. Davies, K. J. Willson, A. Worsley, and J. S. Robinson
Dietary Composition of Pregnant Women Is Related to Size of the Baby at Birth
J. Nutr., July 1, 2004; 134(7): 1820 - 1826.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. Herrick, D. I. W. Phillips, S. Haselden, A. W. Shiell, M. Campbell-Brown, and K. M. Godfrey
Maternal Consumption of a High-Meat, Low-Carbohydrate Diet in Late Pregnancy: Relation to Adult Cortisol Concentrations in the Offspring
J. Clin. Endocrinol. Metab., August 1, 2003; 88(8): 3554 - 3560.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
J. Villar, M. Merialdi, A. M. Gulmezoglu, E. Abalos, G. Carroli, R. Kulier, and M. de Onis
Nutritional Interventions during Pregnancy for the Prevention or Treatment of Maternal Morbidity and Preterm Delivery: An Overview of Randomized Controlled Trials
J. Nutr., May 1, 2003; 133(5): 1606S - 1625.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
J. Villar, M. Merialdi, A. M. Gulmezoglu, E. Abalos, G. Carroli, R. Kulier, and M. de Onis
Characteristics of Randomized Controlled Trials Included in Systematic Reviews of Nutritional Interventions Reporting Maternal Morbidity, Mortality, Preterm Delivery, Intrauterine Growth Restriction and Small for Gestational Age and Birth Weight Outcomes
J. Nutr., May 1, 2003; 133(5): 1632S - 1639.
[Full Text] [PDF]

Home page
 J. Nutr.Home page
C. Hobel and J. Culhane
Role of Psychosocial and Nutritional Stress on Poor Pregnancy Outcome
J. Nutr., May 1, 2003; 133(5): 1709S - 1717.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. W. Shiell, M. Campbell-Brown, S. Haselden, S. Robinson, K. M. Godfrey, and D. J.P. Barker
High-Meat, Low-Carbohydrate Diet in Pregnancy: Relation to Adult Blood Pressure in the Offspring
Hypertension, December 1, 2001; 38(6): 1282 - 1288.
[Abstract] [Full Text] [PDF]

Home page
 Br Med BullHome page
D. J P Barker
The malnourished baby and infant: Relationship with Type 2 diabetes
Br. Med. Bull., November 1, 2001; 60(1): 69 - 88.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
R. S. Strauss and W. H. Dietz
Low Maternal Weight Gain in the Second or Third Trimester Increases the Risk for Intrauterine Growth Retardation
J. Nutr., May 1, 1999; 129(5): 988 - 993.
[Abstract] [Full Text]

Home page
 PediatricsHome page
T. Gonzalez-Cossio, K. E. Peterson, L.-H. Sanin, E. Fishbein, E. Palazuelos, A. Aro, M. Hernandez-Avila, and H. Hu
Decrease in Birth Weight in Relation to Maternal Bone-Lead Burden
Pediatrics, November 1, 1997; 100(5): 856 - 862.
[Abstract] [Full Text] [PDF]