PEDIATRICS Vol. 65 No. 3 March 1980, pp. 573-574
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Syngeneic Bone Marrow Transplantation in a Patient with Metastatic Neuroblastoma Refractory to Conventional Therapy

Wayne E. Spruce 1, Karl G. Blume 1, Owen B. Ellington 1, Gerhard M. Schmidt 1, and Jaime Zusman 1

1 Department of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, California; and the Department of Pediatrics, Tulane University School of Medicine, New Orleans

A child with metastatic neuroblastoma refractory to conventional chemotherapy was treated with lethal doses of chemotherapy and total body irradiation followed by syngeneic bone marrow transplantation. A complete remission was achieved. However, the tumor recurred after six months, and the patient succumbed to disseminated neuroblastoma nine months after marrow grafting.

Submitted on April 26, 1979
Accepted on June 19, 1979