PEDIATRICS Vol. 65 No. 3 March 1980, pp. 547-549
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Theophylline-Induced Seizures in Accidentally Overdosed Neonates

Peter Gal PharmD1, Craig Roop PharmD1, Helen Robinson MD1, and N. Vildan Erkan MD1

1 Department of Neonatology, Georgia Baptist Medical Center, and Clinical Pharmacy, Mercer University Southern School of Pharmacy, Atlanta

Theophylline-induced seizures are reported in two neonates. The serum theophylline concentrations during seizures were 51.0 mg/liter and 54.0 mg/liter. Toxic symptoms prior to seizures may be absent or undetected, supporting the necessity of blood level monitoring during theophylline therapy.

Submitted on March 20, 1979
Accepted on May 14, 1979




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R. R. Clancy, K. M. Kaplan, S. Baumgart, and K. R. Rosenberry
Neonatal Theophylline Neurotoxicity
Clinical Pediatrics, March 1, 1985; 24(3): 168 - 170.
[Abstract] [PDF]