PEDIATRICS Vol. 65 No. 2 February 1980, pp. 326-330
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Hypoglycemia and Unilateral Pulmonary Edema in a Newborn

Kathryn W. Kerkering MD1, Louise W. Robertson MD1, Michael B. Kodroff MD1, Dawn G. Mueller MD1, and Barry V. Kirkpatrick MD1

1 Departments of Pediatrics and Radiology, Medical College of Virginia, Richmond

A case of cardiomegaly with unilateral pulmonary edema is presented. The predisposing etiologies were severe hypoglycemia and a hypertonic glucose infusion into a branch of the left lower lobe pulmonary vein. Resolution resulted following maintenance of adequate glucose levels, vigorous cardiopulmonary support, and repositioning of the catheter tip in the inferior vena cava. The pathophysiologic mechanism was direct endothelial injury with an osmotic diuresis. The role of the release of a vasoactive substance was postulated.

Submitted on February 12, 1979
Accepted on June 6, 1979