PEDIATRICS Vol. 65 No. 2 February 1980, pp. 298-300
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Hypochloremic Metabolic Alkalosis Following Tolazoline-Induced Gastric Hypersecretion

James M. Adams MD1, William H. Hyde MD1, Renato S. Procianoy MD1, and Arnold J. Rudolph MD1

1 Newborn Section, Department of Pediatrics, Baylor College of Medicine, and the Neonatal Intensive Care Unit, Texas Children's Hospital, Houston

Gastric hypersecretion following administration of tolazoline resulted in severe hypochloremic alkalosis in an infant with persistent fetal circulation. An initial bolus injection of 2 mg/kg was followed by an infusion of 5 mg/kg/hr for 24 hours. The infusion was then maintained at 2 mg/kg/hr for the next four days. Volume of gastric secretions exceeded 25 ml/kg/24 hr. Weaning from tolazoline and replacement of chloride and potassium corrected the metabolic alkalosis.




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R. G. Dillard
Fatal Gastrointestinal Hemorrhage in a Neonate Treated with Tolazoline
Clinical Pediatrics, December 1, 1982; 21(12): 761 - 762.
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