PEDIATRICS Vol. 65 No. 2 February 1980, pp. 264-268
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Outbreak of Amikacin-Resistant Enterobacteriaceae in an Intensive Care Nursery

Larry N. Cook MD1, Ray S. Davis MD1, and Beth H. Stover RN1

1 Division of Neonatal Medicine, University of Louisville School of Medicine, and the Children's Hospital, Louisville

An outbreak of amikacin-resistant Enterobacteriaceae (KES) occurred in the Intensive Care Nursery (ICN) of the Louisville General Hospital from January 1978 through March 1978. Epidemic disease and an increased colonization rate in newborn infants due to amikacin-resistant microorganisms has not been documented previously. Three of the 11 neonates died. The organisms isolated were resistant to amikacin and two experimental aminoglycosides, sissomicin and netilmicin. The outbreak was contained following institution of several control measures, including pharyngeal inoculation of an experimental strain of agr streptococcus in four infants.

Submitted on April 12, 1979
Accepted on June 18, 1979




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