PEDIATRICS Vol. 65 No. 1 January 1980, pp. 65-68
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Haemophilus influenzae Type b in a Day Care Center: Relationship of Nasopharyngeal Carriage to Development of Anticapsular Antibody

Dan M. Granoff MD1, Janet Gilsdorf MD1, Charles E. Gessert MD1, and Lawrence Lowe MA1

1 Valley Medical Center of Fresno, Fresno, California, and Department of Pediatrics, East Carolina University School of Medicine, Greenville, North Carolina

We measured anticapsular antibody to Haemophilus influenzae type b by radioimmunoassay in sera from 55 children attending a day care center in which two cases of H influenzae type b disease had occurred. The children ranged in age from 2 months to 36 months. Serum antibody levels in children attending the day care center were significantly higher than in age-matched controls (P .001), but in two different surveys one month apart 38% and 43% of the contacts had levels 100 ng/ ml. Day care center children who were carriers of H influenzae type b had higher geometric mean antibody levels than noncarriers (478 ng/ml compared to 92 ng/ml, P .004). Nevertheless, six of 21 children (29%) with repeatedly positive cultures during four weeks of observation had concentrations of serum antibody 100 ng/ml when measured both by binding the 125I-derivative of the capsular antigen (polyribosyl-ribitol phosphate), or binding of 3H-polyribosyl-ribitol phosphate. These data may explain observations of H influenzae type b disease in contacts of cases more than 30 days after hospitalization of the index patient.

Submitted on March 21, 1979
Accepted on May 29, 1979




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