PEDIATRICS Vol. 65 No. 1 January 1980, pp. 61-64
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Attempts at Use of Strychnine Sulfate in the Treatment of Nonketotic Hyperglycinemia

Kaye D. MacDermot MD1, William Nelson MD1, Cheryl M. Reichert MD, PhD1, and Joseph D. Schulman MD1

1 Section on Human Biochemical and Developmental Genetics, National Institute of Child Health and Human Development, and Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

In two cases of nonketotic hyperglycinemia treated from early ages with strychnine sulphate, the patients demonstrated persistent severe psychomotor retardation and seizures. Strychnine therapy improved tone and feeding, but did not seem to alter fundamentally the course of the disease in either patient.

Submitted on March 1, 1979
Accepted on June 7, 1979




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K. Sankaran, R.E. Casey, W.A. Zaleski, and I.M. Mendelson
Glycine Encephalopathy in a Neonate: Treatment with Intravenous Strychnine and Sodium Benzoate
Clinical Pediatrics, October 1, 1982; 21(10): 636 - 637.
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