PEDIATRICS Vol. 65 No. 1 January 1980, pp. 44-49
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Effect of Respiration on the Echocardiogram in Children with Cystic Fibrosis

David P. Morin MD1, Carol M. Cottrill MD1, Gregory L. Johnson MD1, H. David Wilson MD1, Donald L. Vine MD1, and Jacqueline A. Noonan MD1

1 Departments of Pediatrics and Medicine, University of Kentucky College of Medicine, Lexington

Respiration-related cyclic variation was noted in echocardiographic measurements of right and left ventricular end-diastolic dimension, D-E amplitude of the anterior mitral leaflet, and mitral valve E-F slope in 26 children with cystic fibrosis. The observed echographic changes seem to be an exaggeration of the normal physiologic variation seen with respiration. In children with advanced respiratory disease, airway obstruction, rather than cor pulmonale, may be responsible for this exaggeration.

Submitted on January 25, 1979
Accepted on April 2, 1979