PEDIATRICS Vol. 65 No. 1 January 1980, pp. 18-20
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Angel Dust: Possible Effects on the Fetus

Nancy L. Golden MD1, Robert J. Sokol MD1, and I. Leslie Rubin MD1

1 Departments of Pediatrics, Obstetrics, and Gynecology, and the Perinatal Clinical Research Center, Cleveland Metropolitan General Hospital, Case Western Reserve University, Cleveland

A case report of an infant whose mother used phencyclidine (PCP, "angel dust") during pregnancy is presented. As a neonate, the infant showed abnormal behavior and an unusual appearance, and later, spastic quadriparesis. Based on previous animal studies, it is likely that this infant had prolonged exposure to PCP as a fetus. His abnormal neonatal behavior was consistent with previously reported effects of this drug. The relationship between his exposure to PCP and his dysmorphology and spasticity remains speculative. It is suggested that clinicians be alert to further cases of these associations.

Submitted on February 1, 1979
Accepted on June 7, 1979