PEDIATRICS Vol. 65 No. 1 January 1980, pp. 121-124
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Concentration of Human Chorionic Gonadotropin in the Cerebrospinal Fluid of Patients with Germinal Cell Hypothalamic Tumors

Richard M. Jordan MD1, John W. Kendall MD1, Michael McClung MD1, and Huldrick Kammer MD1

1 Division of Endocrinology, Wilford Hall USAF Medical Center, San Antonio, Texas; and the Research Service, Veterans Administration Hospital; Department of Medicine, University of Oregon Health Sciences Center; and Providence Medical Center, Portland, Oregon

Plasma and cerebrospinal fluid (CSF) specimens were measured simultaneously for human chorionic gonadotropin (HCG) in two patients with HCG- secreting choriocarcinoma. In the patients with hypothalamic tumors, the CSF HCG levels were higher than the plasma HCG concentrations. In the patient with gestational choriocarcinoma with no known cerebral metastases, the plasma HCG level greatly exceeded the CSF HCG concentration. The finding of a CSF HCG concentration that approaches or exceeds the plasma value would be a useful screening procedure in localizing a pathologic source of HCG secretion in patients with a suspected hypothalamic tumor. An unexpected finding in the patient who also had a hypothalamic embryonal cell carcinoma and hypocortisolism was an extremely high concentration of a biologically inactive adrenocorticotropic like substance in the CSF.

Submitted on May 5, 1978
Accepted on September 25, 1978