The Importance of Nonrenal Involvement in Hemolytic-Uremic Syndrome
1 Departments of Pediatrics and Pathology, Yale University School of Medicine, New Haven, Connecticut
Fifteen children with the clinical manifestations of hemolytic-uremic syndrome are reported.Prompt recognition of the syndrome and effective therapy for acute renal failure including early dialysis were institured in each case. Analysis of the clinical course and histopathologic features in these patients indicated that early dialysis and effective management of acute renal failure may unmask evidence of nonrenal involvement; microthrombi may be found in a wide distribution of organs, including the brain and myocardium; and extent and severity of nonrenal involvement become an important determinant of ultimate prognosis.
Submitted on July 31, 1978Accepted on November 17, 1978
This article has been cited by other articles:
 |
|
 |
|
  V. K. Derebail, P. Parikh, J. C. Jennette, and A. V. Kshirsagar A rare cause of the pulmonary-renal syndrome: a case of atypical haemolytic-uraemic syndrome complicated by pulmonary haemorrhage NDT Plus, December 1, 2008; 1(6): 417 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. D. Sauter, A. R. Melton-Celsa, K. Larkin, M. L. Troxell, A. D. O'Brien, and B. E. Magun Mouse Model of Hemolytic-Uremic Syndrome Caused by Endotoxin-Free Shiga Toxin 2 (Stx2) and Protection from Lethal Outcome by Anti-Stx2 Antibody Infect. Immun., October 1, 2008; 76(10): 4469 - 4478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Fujii, K. Wood, F. Matsuda, B. A. Carneiro-Filho, K. H. Schlegel, T. Yutsudo, B. Binnington-Boyd, C. A. Lingwood, F. Obata, K. S. Kim, et al. Shiga Toxin 2 Causes Apoptosis in Human Brain Microvascular Endothelial Cells via C/EBP Homologous Protein Infect. Immun., August 1, 2008; 76(8): 3679 - 3689. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Ray, D. Acheson, R. Chitrakar, A. Cnaan, K. Gibbs, G. H. Hirschman, E. Christen, and H. Trachtman Basic Fibroblast Growth Factor among Children with Diarrhea-Associated Hemolytic Uremic Syndrome J. Am. Soc. Nephrol., March 1, 2002; 13(3): 699 - 707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Fujii, Y. Kinoshita, T. Yutsudo, H. Taniguchi, T. Obrig, and S.-I. Yoshida Toxicity of Shiga Toxin 1 in the Central Nervous System of Rabbits Infect. Immun., October 1, 2001; 69(10): 6545 - 6548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Schlieper, E. Orrbine, G. A Wells, M. Clulow, P. N McLaine, and P. C Rowe Neuropsychological sequelae of haemolytic uraemic syndrome Arch. Dis. Child., March 1, 1999; 80(3): 214 - 220. [Abstract] [Full Text]
|
|
|
|
|
|
T. Kurioka, Y. Yunou, and E. Kita Enhancement of Susceptibility to Shiga Toxin-Producing Escherichia coli O157:H7 by Protein Calorie Malnutrition in Mice Infect. Immun., April 1, 1998; 66(4): 1726 - 1734. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mitra, E. A. Jaffe, B. Weksler, K. A. Hajjar, C. Soderland, and J. Laurence Thrombotic Thrombocytopenic Purpura and Sporadic Hemolytic-Uremic Syndrome Plasmas Induce Apoptosis in Restricted Lineages of Human Microvascular Endothelial Cells Blood, February 15, 1997; 89(4): 1224 - 1234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Siegler, M. Loghman-Adham, and O. D. Timmons Acute Respiratory Failure in the Hemolytic Uremic Syndrome Clinical Pediatrics, December 1, 1995; 34(12): 660 - 662. [PDF]
|
|
|
|
|
|
M.S. Ehlayel and K.F. Akl Mucocutaneous Manifestations of the Hemolytic-Uremic Syndrome Clinical Pediatrics, April 1, 1991; 30(4): 208 - 210. [PDF]
|
|
|
|
|
|
F. J. DiMario JR, H. Bronte-Stewart, J. Sherbotie, and M. E. Turner Lacunar Infarction of the Basal Ganglia as a Complication of Hemolytic-uremic Syndrome: MRI and Clinical Correlations Clinical Pediatrics, November 1, 1987; 26(11): 586 - 590. [Abstract] [PDF]
|
|
