PEDIATRICS Vol. 65 No. 1 January 1980, pp. 103-106
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Morning Plasma Cortisol Levels in Infants Treated with Topical Fluorinated Glucocorticosteroids

William L. Weston MD1, W. Mitchell Sams Jr MD1, Helen G. Morris MD1, James M. Arthur MD1, Gordon J. Blakeman MD1, and Mary Andresen Cha1

1 Departments of Dermatology and Pediatrics, University of Colorado School of Medicine, Denver

The plasma cortisol levels of 17 infants of mean age 12.1 months taken at 8 AM were measured before and after application of a topical fluorinated glucocorticosteroid. There was a statistically significant depression of plasma cortisol value in 11 infants at days 3, 7, and 14 after therapy. All of the plasma cortisol levels returned to normal. For the entire group of 17 infants, however, there was no significant depression of plasma cortisol levels. Even in the usual office use of topical glucocorticosteroids, one must be aware of the possibility of percutaneous absorption.

Submitted on August 28, 1978
Accepted on November 7, 1978




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