PEDIATRICS Vol. 64 No. 6 December 1979, pp. 935-938
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Refractory Pneumocystis carinii Infection in Chronic Granulomatous Disease: Successful Treatment with Granulocytes

F. Karup Pedersen MD1, K. Staehr Johansen MD1, Joergen Rosenkvist MD1, lnge Tygstrup MD1, and Niels H. Valerius MD1

1 University Clinic of Paediatrics Department G, Bloodbank, Laboratory of Paediatric Pathology, and Department of Clinical Microbiology of Statens Seruminstitut, Rigshospitalet, Copenhagen

Pneumocystis carinii pneumonia developed in an 11-year-old girl with chronic granulomatous disease who had normal cellular and humoral immunity. The patient remained febrile during treatment with sulfame-thoxazole-trimethoprim and pentamidine but became afebrile when treated with a series of 12 granulocyte transfusions combined with sulfamethoxazole-trimethoprim. In addition to documenting P carinii infection in chronic granulomatous disease our findings suggest that granulocyte transfusions may be of value in the treatment of severe infections in chronic granubomatous disease.

Submitted on June 21, 1978
Accepted on April 10, 1979