PEDIATRICS Vol. 64 No. 6 December 1979, pp. 929-934
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Higginbottom, M. C.
Right arrow Articles by Wilson, C. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Higginbottom, M. C.
Right arrow Articles by Wilson, C. B.

The Cockayne Syndrome: An Evaluation of Hypertension and Studies of Renal Pathology

Marilyn C. Higginbottom MD1, William R. Griswold MD1, Kenneth Lyons Jones MD1, Martha D. Vasquez MD1, Stanley A. Mendoza MD1, and Curtis B. Wilson MD1

1 Department of Pediatrics, University of California at San Diego; the Department of Pathology, Veterans Hospital, La Jolla, and the Department of Immunopathology, Scripps Clinic and Research Foundation, La Jolla, California

Three children with renal disease, hypertension, and the Cockayne syndrome were evaluated. All patients had sevpertension; peripheral vein renin was elevated in two patients. Renal biopsy specimens from two patients were studied by light microscopy, electron microscopy, and immunofluoresence. Immunohistologic studies demonstrated deposits of immunoglobulin and complement in the vessels and glomeruli of the first patient; deposits of immunoglobulin and complement were seen in the glomeruli of the third patient. Also electron-dense deposits were seen in the glomerular basement membrane of the third patient. Circulating immune complexes were detected by the Raji cell and Clq binding techniques in this child as well. Both hypertension and renal disease are frequent complications of the Cockayne syndrome.

Submitted on November 27, 1978
Accepted on March 12, 1979




This article has been cited by other articles:


Home page
 J Child NeurolHome page
I. Rapin, K. Weidenheim, Y. Lindenbaum, P. Rosenbaum, S. N. Merchant, S. Krishna, and D. W. Dickson
Cockayne Syndrome in Adults: Review With Clinical and Pathologic Study of a New Case
J Child Neurol, November 1, 2006; 21(11): 991 - 1006.
[Abstract] [PDF]