PEDIATRICS Vol. 64 No. 6 December 1979, pp. 918-922
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Increase of IgA-Bearing Peripheral Blood Lymphocytes in Children with Henoch-Schoenlein Purpura

Harumi Kuno-Sakai MD1, Hideto Sakai MD1, Yasuo Nomoto MD1, lwao Takakura MD1, and Mikio Kimura MD1

1 Departments of Pediatrics and Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan

Aberration of IgA-bearing peripheral blood lymphocytes in children with Henoch-Schoenlein purpura has been investigated. Eighteen children with Henoch-Schoenlein purpura demonstrated a marked increase of IgA-bearing lymphocytes in peripheral blood during the acute phase of the disease. The levels of IgA-bearing lymphocytes returned to the normal levels after the acute symptoms of Henoch-Schoenlein purpura had subsided. However, in patients who developed purpura nephritis, the increased levels of IgA-bearing lymphocytes in peripheral blood were retained after the disappearance of purpura, and lasted for more than 12 months. It is concluded that the monitoring of IgA-bearing peripheral blood lymphocytes is useful for the screening of patients with Henoch-Schoenlein purpura and purpura nephritis.

Submitted on November 19, 1978
Accepted on April 23, 1979