PEDIATRICS Vol. 64 No. 5 November 1979, pp. 775-780
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Ontogeny of Serum Complement Proteins

Harvey R. Colten MD1 and Gabriel Goldberger MD1

1 Division of Cell Biology, Department of Medicine, Children's Hospital Medical Center, and Department of Pediatrics, Harvard Medical School, Boston

The capacity for complement biosynthesis appears early in gestation. In most species, functional complement and properdin systems are intact by the end of the first trimester. An increase in fetal serum complement concentration (several components) occurs early in the third trimester reaching 30 to 50% of adult levels. The mechanisms for initiation of fetal biosynthesis of complement and the apparent change in rate of synthesis are knknown. The role of complement, if any, in utero is also not known. These will most certainly be subjectics of further investigations.




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[Abstract] [Full Text] [PDF]