PEDIATRICS Vol. 64 No. 5 November 1979, pp. 601-603
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The Prevalence of Cholelithiasis in Sickle Cell Disease as Diagnosed by Ultrasound and Cholecystography

Barry S. Lachman MD, MPH1, Jack Lazerson MD1, Robert J. Starshak MD1, Frank M. Vaughters MD1, and Steven L. Werlin MD1

1 Departments of Pediatrics and Radiology, Medical College of Wisconsin and Milwaukee Children's Hospital, Milwaukee

Gallbladder disease is known to be increased in sickle cell disease (SS). The prevalence of cholelithiasis in children with SS has been reported as 10% to 37%. Gallbladder ultrasound, cholecystography, and/or abdominal radiography were used to evaluate 31 patients aged 2 to 18 years with no systematic evidence of gallbladder disease for cholelithiasis. Overall prevalence of gallstones was found to be 29%. Cholelithiasis was detected in children as young as 4 years of age. Prevalence below the age of 10 years and above the age of 10 years was found to be 11% and 55% respectively. The increased prevalence of cholelithiasis in children with sickle cell disease suggests the use of diagnostic ultrasonography as a routine screening procedure.

Submitted on November 3, 1978
Accepted on March 5, 1979




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