PEDIATRICS Vol. 64 No. 5 November 1979, pp. 598-600
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Pulmonary Excretion of Carbon Monoxide in the Human Newborn Infant as an Index of Bilirubin Production: III. Measurement of Pulmonary Excretion of Carbon Monoxide After the First Postnatal Week in Premature Infants

David K. Stevenson MD1, Albert L. Bartoletti MD1, Clinton R. Ostrander MS1, and John D. Johnson MD1

1 Department of Pediatrics, Stanford University School of Medicine, Stanford, California

Using a single pass, flow-through system, the excretion rate of endogenously produced carbon monoxide ([unknown]eCO) was measured as an index of bilirubin production in 41 Caucasian infants of various gestational ages after the first postnatal week. Twenty-one were le32 weeks gestation. The mean slope for the 25 premature infants with multiple [unknown]eCO determinations was -0.21 ± 0.11 (SE) µl/kg/hour per day (P < .025, one-tailed). Fifteen premature infants with at least three [unknown]eCO determinations during the first 30 days of life had an average decrease in total CO excreted of 1.33% per day compared to the extrapolated initial value of total CO excretion of 27.0 ± 2.0 (SE) µl/hour, giving a calculated maximum red cell life span of 75 days.

Submitted on January 22, 1979
Accepted on March 12, 1979


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C. H. Meyers, L. K. Kwong, H. J. Vreman, and D. K. Stevenson
The Role of Bilirubin Production in Breast-fed Infants with Elevated Serum Bilirubin Concentrations at 2 Weeks of Life
Clinical Pediatrics, September 1, 1984; 23(9): 480 - 482.
[Abstract] [PDF]