PEDIATRICS Vol. 64 No. 4 October 1979, pp. 499-505
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Clinical Hepatotoxicity of Isoniazid in Children

Martin T. Stein MD1 and Dora Liang PharmD1

1 Department of Pediatrics, University of California, San Diego, and the Division of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco (San Diego Program)

A patient is presented with reversible clinical and biochemical hepatocellular injury secondary to isoniazid (INH). This apparently rare drug reaction in children is compared with the more common transient hypertransaminasemia induced by isomazid. A review of the clinical literature and basic pharmacologic mechanisms of isoniazid-induced hepatotoxicity has led to a rational plan for monitoring and managing children who are treated with INH.

Submitted on October 24, 1978
Accepted on January 18, 1979




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