PEDIATRICS Vol. 64 No. 3 September 1979, pp. 387
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Pathogenesis of Intraventricular Hemorrhage

Kenneth L. Wible MD1

1 Associate Professor, Department of Pediatrics, West Virginia University School of Medicine, Morgantown, WV 26505

The article by Kenny et al (Pediatrics 62:465, 1978) on the pathogenesis of intraventricular hemorrhage has prompted some thoughts regarding the role of rapid infusion of concentrated bicarbonate solutions and their relationship to neonatal intracranial hemorrhage. I should like to suggest that perhaps rather than the osmotic influences as has often been suggested, we may be dealing with the pharmacologic effect of excessive amounts of CO2 transiently generated in the cerebral capillary bed by the reaction of these concentrated solutions with excessive free hydrogen ion.