PEDIATRICS Vol. 64 No. 3 September 1979, pp. 361-368
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Biochemical Alterations in Neonatal Hyperbilirubinemia and Bilirubin Encephalopathy: A Review

Warren B. Karp PhD, DMD1

1 Department of Pediatrics, Medical College of Georgia, Augusta

This review article discusses some current questions concerning the measurement of bilirubin in the blood of newborn infants and the relationship of these blood parameters to the biochemical defects responsible for bilirubin encephalopathy. A discussion of numerous theories, which have been put forth to explain the specific biochemical mechanism by which bilirubin acts on brain metabolism, demonstrates that presently there is no un- equivocal explanation for the molecular events leading to bilirubin encephalopathy.

Submitted on September 21, 1978
Accepted on February 5, 1979




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