PEDIATRICS Vol. 64 No. 3 September 1979, pp. 326-332
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Nonimmune Hydrops Fetalis: Report of 22 Cases Including Three Siblings

P. C. Etches MB, MRCP1 and James A. Lemons MD1

1 Department of Perinatology, Children's Hospital, Denver, and the Department of Pediatrics, University of Colorado Medical Center, Denver

Twenty-two cases of nonimmune hydrops fetalis (NIHF) seen over a three-year period are described. Eight cases were associated with major congenital anomalies, seven cases with minor anomalies or other disease entities, and seven idiopathic cases. The overall mortality rate was 50%, greatest in those cases complicated by major anomalies. The clinical problems commonly encountered in management of these patients are reviewed, and include prenatal detection, perinatal asphyxia, disseminated intravascular coagulopathy, fluid and electrolyte imbalance, and respiratory difficulty. A review of the literature for those entities found in association with NIHF is also included. The case studies of three consecutive siblings with NIHF born to the same parents are briefly analyzed.

Submitted on December 27, 1978
Accepted on February 22, 1979




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